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A type of white blood cell that plays a critical role in the immune system’s response to pathogens. There are a number of different kinds of t-cells. In HIV research and treatment, people often refer specifically to T-helper cells, also called CD4+ cells. These cells coordinate the activity of many other immune system cells. HIV invades and weakens or destroys T-helper cells. Physicians regularly monitor the level of T-helper cells in people with HIV infection to measure the progression of disease. Definition From Negative or Postive.